Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503907 | 0.87 | SCN9A (0.39) | SCN9AKCNH2SCN5AMTNR1A | |
| SCHEMBL28356770 | 0.80 | MTNR1A (0.45) | MTNR1A | |
| SCHEMBL19054490 | 0.79 | TP53 (0.44) | KMT2AL3MBTL1SCN9AKCNH2SCN5A | |
| SCHEMBL19667663 | 0.79 | EPHX2 (0.43) | KMT2AL3MBTL1SCN9AKCNH2SCN5A | |
| SCHEMBL31498775 | 0.77 | GAA (0.39) | KMT2AL3MBTL1EPHX2GAAUSP30 | |
| SCHEMBL29771969 | 0.77 | GAA (0.36) | KMT2AL3MBTL1EPHX2GAAUSP30 | |
| SCHEMBL1875351 | 0.77 | GAA (0.36) | KMT2AL3MBTL1EPHX2GAAUSP30 | |
| SCHEMBL1875354 | 0.77 | GAA (0.36) | KMT2AL3MBTL1EPHX2GAAUSP30 | |
| SCHEMBL1878236 | 0.77 | GAA (0.36) | KMT2AL3MBTL1EPHX2GAAUSP30 | |
| SCHEMBL31704275 | 0.75 | PRMT5 (0.44) | EPHX2GAAUSP30KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |