SCHEMBL8778835

SCHEMBL8778835

Fc1ncccc1C(Cl)(Cl)Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 1/20 0.41
KCNA5 P22460 1/20 0.35
KCNH2 Q12809 1/20 0.35
CYP11B2 P19099 1/20 0.33
EPHX2 P34913 1/20 0.33
PDE4B Q07343 1/20 0.32
PDE4D Q08499 1/20 0.32
NFE2L2 Q16236 3/20 0.31
HSD11B1 P28845 1/20 0.31
KDM4E B2RXH2 3/20 0.31
MAPT P10636 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
GMNN O75496 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
HSP90AA1 P07900 1/20 0.31
MMP2 P08253 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
MMP9 P14780 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10354468 0.84 NAPRT (0.39) NAPRTKCNA5KCNH2CYP11B2EPHX2
SCHEMBL610024 0.79 EPHX2 (0.44) NAPRTKCNA5KCNH2EPHX2NFE2L2
SCHEMBL31009386 0.79 EPHX2 (0.44) NAPRTKCNA5KCNH2EPHX2NFE2L2
SCHEMBL2616434 0.77 NAPRT (0.41) NAPRTKCNA5KCNH2KDM4ETDP1
SCHEMBL16472118 0.77 NAPRT (0.41) NAPRTKCNA5KCNH2KDM4ETDP1
SCHEMBL30046969 0.74 SMN1; SMN2 (0.42) NFE2L2KDM4EMAPTTDP1LMNA
SCHEMBL10354989 0.74 KDM4E (0.32) EPHX2KDM4EMAPTTDP1GMNN
SCHEMBL4764441 0.74 SMN1; SMN2 (0.42) NFE2L2KDM4EMAPTTDP1LMNA
SCHEMBL646416 0.74 NAPRT (0.42) NAPRTKCNA5KCNH2HSD11B1KDM4E
SCHEMBL363908 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700903-B1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL IND CO (JP) 1997-11-12 EP disclosed
US-5675012-A REACTING AMMONIUM HALIDE WITH TRICHLOROMETHYLPYRIDINE IN PRESENCE OF A COPPER AND ZINC COMPOUND IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1997-10-07 US disclosed
EP-0700903-A1 PROCESS FOR PRODUCING CYANOPYRIDINE IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-03-13 EP disclosed