Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MGAM | O43451 | 1/20 | 0.56 |
| ▸ | SI | P14410 | 1/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16150878 | 0.86 | LCK (0.61) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL10532529 | 0.78 | MAPT (0.58) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL8177453 | 0.77 | NPC1 (0.67) | ALDH1A1HTTRAB9ANPC1ABL1 | |
| SCHEMBL8779332 | 0.77 | NPC1 (0.63) | ALDH1A1HTTRAB9AGAAMEN1 | |
| SCHEMBL8779275 | 0.77 | NPC1 (0.62) | ALDH1A1LMNAHTTRAB9AGAA | |
| SCHEMBL3906094 | 0.77 | MAPK1 (0.62) | ALDH1A1MAPTLMNAHTTRAB9A | |
| SCHEMBL10363026 | 0.77 | MAPT (0.67) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL8779378 | 0.76 | ABL1 (0.70) | ALDH1A1MAPTLMNAHTTTP53 | |
| SCHEMBL14426475 | 0.75 | LMNA (0.74) | ALDH1A1MAPTLMNAHTTRAB9A | |
| SCHEMBL7481344 | 0.75 | NPC1 (0.56) | ALDH1A1HTTRAB9AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579129-B1 | Thiadiazole derivatives for the treatment of depressive states | CT LAB FARM SRL (IT) | 1997-03-05 | — | — | EP | claimed |
| EP-0579129-A2 | Thiadiazole derivatives for the treatment of depressive states | LABORATORIO FARMACEUTICO C.T. S.r.l. (IT) | 1994-01-19 | — | — | EP | claimed |