Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779460 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL5019087 | 0.89 | LMNA (0.61) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL4923251 | 0.88 | LMNA (0.54) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL16691163 | 0.88 | LMNA (0.54) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL16691249 | 0.88 | LMNA (0.54) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL12667027 | 0.87 | LMNA (0.52) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL28017694 | 0.87 | HTT (0.61) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| SCHEMBL19390721 | 0.87 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 | |
| Hydrochloric Acid SCHEMBL10865002 | 0.86 | HDAC3 (0.52) | LMNASMN1; SMN2ALDH1A1DPP4KMT2A | |
| SCHEMBL1568538 | 0.85 | LMNA (0.56) | LMNASMN1; SMN2HTTSLC1A3SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813519-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-12-29 | — | — | EP | disclosed |