Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.36 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29776423 | 0.98 | TSHR (0.58) | TSHRHPGDALDH1A1TP53HIF1A | |
| Bromide SCHEMBL20235975 | 0.96 | TSHR (0.56) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL5385813 | 0.90 | TSHR (0.62) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL21294051 | 0.88 | TSHR (0.61) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL13726546 | 0.88 | TSHR (0.65) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL1476986 | 0.88 | TSHR (0.65) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL2019272 | 0.87 | TSHR (0.53) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL7619758 | 0.87 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL7621998 | 0.87 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL28563692 | 0.87 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106749890-A | A kind of PAMC reversed-phase emulsion and preparation method thereof | 新乡市凯源环保材料有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-111378070-B | Preparation method and application of fracturing thickening agent | 东营市盛聚化工有限责任公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-111378070-A | Preparation method and application of fracturing thickening agent | 东营市盛聚化工有限责任公司 | 2020-07-07 | — | — | CN | disclosed |
| CN-106749890-A | A kind of PAMC reversed-phase emulsion and preparation method thereof | 新乡市凯源环保材料有限公司 | 2017-05-31 | — | — | CN | disclosed |
| EP-0525751-B1 | Process for the preparation of an aqueous dispersion of water-soluble cationic polymer | HYMO CORP (JP) | 1997-06-25 | — | — | EP | disclosed |
| US-5587415-A | FLOCCULANT, PAPER CHEMISTRY | HYMO CORPORATION (JP) | 1996-12-24 | — | — | US | disclosed |
| EP-0525751-A1 | Process for the preparation of dispersion of water-soluble cationic polymer | HYMO CORPORATION (JP) | 1993-02-03 | — | — | EP | disclosed |