Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13800992 | 0.98 | DRD2 (0.66) | DRD2HTR6GPR119MLYCDNR1H2 | |
| SCHEMBL21442594 | 0.85 | DRD2 (0.71) | DRD2HTR6GPR119MLYCDNR1H2 | |
| SCHEMBL17893525 | 0.83 | DRD2 (0.61) | DRD2HTR6GPR119MLYCDNR1H2 | |
| SCHEMBL3454087 | 0.83 | HTR6 (0.70) | DRD2HTR6 | |
| SCHEMBL23043686 | 0.83 | HTR6 (0.58) | DRD2HTR6MEN1ALDH1A1KMT2A | |
| SCHEMBL29978549 | 0.83 | HTR6 (0.58) | DRD2HTR6MEN1ALDH1A1KMT2A | |
| SCHEMBL17856468 | 0.83 | CA1 (0.53) | HTR6KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL12367089 | 0.82 | DRD2 (0.59) | DRD2HTR6GPR119MLYCDNR1H2 | |
| SCHEMBL38652751 | 0.81 | CA1 (0.55) | DRD2HTR6KDM4EMEN1ALDH1A1 | |
| SCHEMBL38652729 | 0.81 | HTR6 (0.54) | DRD2HTR6KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100345833-C | Modulators of dopamine neurotransmission | CARLSSON RES AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1255382-C | Novel modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2006-05-10 | — | — | CN | disclosed |
| CN-1765890-A | Modulators of dopamine neurotransmission | CARLSSON RES AB (SE) | 2006-05-03 | — | — | CN | disclosed |
| CN-1420869-A | Novel modulators of dopamine neurotransmission | CARLSSON A RESEARCH AB (SE) | 2003-05-28 | — | — | CN | disclosed |
| EP-0783486-A1 | NOVEL PROSTAGLANDIN SYNTHASE INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-07-16 | — | — | EP | disclosed |