SCHEMBL8780

SCHEMBL8780

C1=NNc2ccccc2-c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
NOS2 P35228 2/20 0.32
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30
PDGFRA P16234 1/20 0.30
FER P16591 1/20 0.30
LTK P29376 1/20 0.30
CDK8 P49336 1/20 0.30
ACVR1 Q04771 1/20 0.30
LRRK2 Q5S007 1/20 0.30
DYRK1B Q9Y463 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3536526 0.76 NISCH (0.33) GAAMAPTPDGFRALTKACVR1
SCHEMBL28780480 0.73 PDK2 (0.38)
SCHEMBL752653 0.68 GRK6 (0.37) GAAMAPT
SCHEMBL31154216 0.67 GAA (0.32) GAAMAPT
SCHEMBL5325946 0.67 MAPT (0.41) GAAMAPTMAOAMAOBPDGFRA
SCHEMBL8102711 0.67 MAPT (0.41) GAAMAPT
SCHEMBL31390287 0.66
Hydrochloric Acid SCHEMBL4483575 0.65 GAA (0.31) GAAMAPTNOS2
SCHEMBL5604886 0.65 GAA (0.34) GAAMAPT
SCHEMBL3501047 0.65 POLB (0.31) MAPTDYRK1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250377301-A1 STABILISED FLUOROPHORES, COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE FREISTAAT BAYERN LUDWIG MAXIMILIANS UNIV MUENCHEN (DE) 2025-12-11 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20250120980-A1 DIBENZODIAZEPINE COMPOUNDS AND USE IN INTERFERON ACTIVATOR PROTEIN AGONISTS THEREOF HEBEI GRANDIOS PHARMA CO, LTD. (CN) 2025-04-17 US claimed
CN-116987040-A Dibenzodiazepine derivative and preparation method and application thereof 中国中医科学院中药研究所 2023-11-03 CN claimed
CN-116854643-A Synthesis method of dibenzodiazepine or oxyazepine compound 中山大学 2023-10-10 CN claimed
CN-114349714-B Dibenzodiazepine derivative and preparation method and application thereof 华中师范大学 2023-09-29 CN claimed
CN-114349714-A Dibenzodiazepine derivative and preparation method and application thereof 华中师范大学 2022-04-15 CN claimed
EP-3812373-A1 NOVEL COMPOUND BINDING TO DESIGNER RECEPTOR, IMAGING METHOD FOR DESIGNER RECEPTOR, AGONIST OR ANTAGONIST, THERAPEUTIC AGENT, COMPANION DIAGNOSTIC AGENT, AND IMAGING METHOD FOR NERVE CELL NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY (JP) 2021-04-28 EP claimed
US-20190125825-A1 SMALL-MOLECULE ADJUVANTS FOR ANTIBIOTICS TO ADDRESS ANTIBIOTIC RESISTANCE HIGH POINT UNIVERSITY 2019-05-02 US claimed
US-9974839-B2 Self-assembled toroidal-spiral particles and manufacture and uses thereof THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-05-22 US claimed
US-4938758-A Anti-pathogenic blood collection system and method AL SIOUFI HABIB (US) 1990-07-03 US claimed
EP-0263873-A4 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD. AL-SIOUFI HABIB 1989-07-11 EP claimed
EP-0263873-A1 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD AL-SIOUFI, Habib (US) 1988-04-20 EP claimed
WO-1987006119-A1 ANTI-PATHOGENIC BLOOD COLLECTION SYSTEM AND METHOD AL SIOUFI HABIB 1987-10-22 WO claimed
US-4654323-A BLOCKING AGENT FOR CALCIUM CALMODULIN COMPLEX BAR ILAN UNIVERSITY (IL) 1987-03-31 US claimed
EP-0168626-A1 Composition for the manufacture of a medicament for the therapeutic treatment of trauma of the skin BAR-ILAN UNIVERSITY (IL) 1986-01-22 EP claimed
EP-0085892-B1 SUBSTITUTED BENZODIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1985-12-18 EP claimed
US-4377577-A Use of psychoactive drugs in uterus to prevent pregnancy UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1983-03-22 US claimed
EP-0053108-A1 VAGINAL CONTRACEPTIVES COMPRISING PSYCHOACTIVE DRUGS THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 1982-06-09 EP claimed
WO-1981003421-A1 USE OF PSYCHOACTIVE DRUGS AS VAGINAL CONTRACEPTIVES UNIV GEORGIA (US) 1981-12-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190125825-A1 SMALL-MOLECULE ADJUVANTS FOR ANTIBIOTICS TO ADDRESS ANTIBIOTIC RESISTANCE MYD88, TLR5, TLR3 GAA 3627/4885MAPT 4861/4885NOS2 3565/4885
US-20250377301-A1 STABILISED FLUOROPHORES, COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE CRY1, MKI67, IK GAA 3939/4885MAPT 1613/4885NOS2 312/4885
US-20250120980-A1 DIBENZODIAZEPINE COMPOUNDS AND USE IN INTERFERON ACTIVATOR PROTEIN AGONISTS THEREOF STING1, IRF3, IFNAR1 GAA 1045/4885MAPT 3812/4885NOS2 3647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.