Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MIF | P14174 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780459 | 1.00 | RXRA (0.56) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9391471 | 0.89 | CES1 (0.45) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9391477 | 0.89 | CES1 (0.45) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL9391470 | 0.89 | CES1 (0.45) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL16168486 | 0.87 | RXRA (0.45) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8923628 | 0.84 | RXRA (0.60) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL12629637 | 0.84 | RXRA (0.60) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8923632 | 0.84 | RXRA (0.60) | RXRANOTUMCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3253387 | 0.81 | RXRA (0.60) | RXRACYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL13545387 | 0.79 | RXRA (0.52) | RXRACYP19A1CYP11B1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759025-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-02-26 | — | — | EP | disclosed |
| WO-1995030644-A1 | AMIDE DERIVATIVES AND THEIR THERAPEUTIC USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |