SCHEMBL8780463

SCHEMBL8780463

COc1cc(N)cc2c1OC1(C=C2)N(Cc2ccc(F)cc2F)c2ccccc2C1(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.42
MAPT P10636 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
LMNA P02545 2/20 0.42
RECQL P46063 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
PLIN1 O60240 1/20 0.42
THRB P10828 1/20 0.42
PKM P14618 1/20 0.42
TSHR P16473 1/20 0.42
PLIN5 Q00G26 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ABHD5 Q8WTS1 1/20 0.42
NPSR1 Q6W5P4 2/20 0.33
ALPG P10696 1/20 0.33
TP53 P04637 1/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33
P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13300482 0.91 GAA (0.43) GAAMAPTKMT2AMEN1LMNA
SCHEMBL14327434 0.89 GAA (0.42) GAAMAPTKMT2AMEN1LMNA
SCHEMBL13419419 0.88 GAA (0.41) GAAMAPTKMT2AMEN1LMNA
SCHEMBL8778055 0.87 MAPT (0.40) GAAMAPTKMT2AMEN1LMNA
SCHEMBL13258584 0.82 GAA (0.44) GAAMAPTKMT2AMEN1LMNA
SCHEMBL8778070 0.82 GAA (0.41) GAAMAPTKMT2AMEN1LMNA
SCHEMBL13491012 0.81 MAPT (0.41) GAAMAPTKMT2AMEN1LMNA
SCHEMBL14802201 0.79 MAPT (0.44) GAAMAPTKMT2AMEN1LMNA
SCHEMBL8776281 0.79 MAPT (0.36) GAAMAPTKMT2AMEN1LMNA
SCHEMBL14140952 0.78 MAPT (0.41) GAAMAPTKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102307-B1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2012-05-23 EP disclosed