Phenylurea

Phenylurea

SCHEMBL8780484

NC(=O)Nc1ccccc1.O=C(Nc1ccccc1)Nc1ccnc(Cl)c1

nearest known ligand 0.68

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMARCA2 P51531 9/20 0.68
SMARCA4 P51532 8/20 0.68
CNR1 P21554 1/20 0.54
TAAR1 Q96RJ0 1/20 0.53
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
MAPT P10636 4/20 0.53
RAB9A P51151 2/20 0.53
NPC1 O15118 2/20 0.53
LMNA P02545 2/20 0.53
HTT P42858 2/20 0.53
KDR P35968 2/20 0.52
NPSR1 Q6W5P4 1/20 0.50
GAA P10253 1/20 0.49
GFER P55789 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TP53 P04637 1/20 0.49
EPHX1 P07099 1/20 0.49
TSHR P16473 1/20 0.49
EPHX2 P34913 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL119685 0.93 SMARCA2 (0.79) SMARCA2SMARCA4CNR1TAAR1MEN1
SCHEMBL9278345 0.88 SMARCA2 (0.65) SMARCA2SMARCA4NPC1
SCHEMBL9599834 0.84 SMARCA2 (0.86) SMARCA2SMARCA4CNR1MEN1KMT2A
Phenylurea SCHEMBL27479524 0.84 MAPT (0.50) SMARCA2SMARCA4CNR1MEN1KMT2A
Nitric Acid SCHEMBL28189380 0.82 SMARCA2 (0.63) SMARCA2SMARCA4CNR1TAAR1MEN1
SCHEMBL22125200 0.82 SMARCA2 (1.00) SMARCA2SMARCA4TAAR1MEN1KMT2A
SCHEMBL22154745 0.81 DDX3X (0.68) SMARCA2SMARCA4MEN1KMT2AMAPT
SCHEMBL9410880 0.81 MEN1 (0.72) SMARCA2SMARCA4MEN1KMT2AMAPT
SCHEMBL11047103 0.80 SMARCA2 (0.79) SMARCA2SMARCA4CNR1MEN1KMT2A
Phenylurea SCHEMBL27866585 0.80 GAA (0.56) SMARCA2SMARCA4MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808372-A1 AGROBACTERIUM MEDIATED TRANSFORMATION OF EUCALYPTUS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1997-11-26 EP disclosed
WO-1996025504-A1 GENETIC MODIFICATION OF PLANTS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1996-08-22 WO disclosed