Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.87 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.87 |
| ▸ | LMNA | P02545 | 6/20 | 0.87 |
| ▸ | PGR | P06401 | 6/20 | 0.87 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.77 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.70 |
| ▸ | AR | P10275 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone Acetonide SCHEMBL1446089 | 0.98 | HIF1A (0.89) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL1561091 | 0.98 | HIF1A (0.89) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL14782684 | 0.95 | HIF1A (0.97) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL2229029 | 0.95 | HIF1A (0.97) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL13839748 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL16393966 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL4002585 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL21051778 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL11911289 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR | |
| Triamcinolone Acetonide SCHEMBL1639690 | 0.93 | HIF1A (1.00) | HIF1ACYP3A4LMNANR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767115-B | Therapeutic interferon alpha 1 proteins | 奥里尼斯生物科学股份有限公司 | 2025-05-02 | — | — | CN | disclosed |
| EP-0727978-A4 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON VICKS INC (US) | 1997-01-29 | — | — | EP | disclosed |
| EP-0727978-A1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON-VICKS, INC. (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1992021323-A1 | USE OF LYSOPHOSPHATE ACIDS FOR THE TREATMENT OF SKIN WRINKLES | THE PROCTER & GAMBLE COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |