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Triamcinolone Acetonide

Triamcinolone Acetonide

SCHEMBL1561091

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 6/20 0.89
▸ HIF1A Q16665 9/20 0.89
▸ CYP3A4 P08684 8/20 0.89
▸ LMNA P02545 6/20 0.89
▸ PGR P06401 6/20 0.89
▸ NR1I2 O75469 1/20 0.89
▸ HSD17B10 Q99714 5/20 0.79
▸ NFKB1 P19838 3/20 0.79
▸ CYP2C9 P11712 2/20 0.79
▸ PMP22 Q01453 2/20 0.79
▸ CYP2J2 P51589 1/20 0.79
▸ BLM P54132 1/20 0.79
▸ CYP2C19 P33261 1/20 0.79
▸ NPSR1 Q6W5P4 3/20 0.71
▸ AR P10275 3/20 0.69
▸ TSHR P16473 2/20 0.69
▸ MEN1 O00255 1/20 0.69
▸ CYP2D6 P10635 1/20 0.69
▸ KMT2A Q03164 1/20 0.69
▸ APEX1 P27695 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triamcinolone Acetonide SCHEMBL1446089 1.00 HIF1A (0.89) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL8780600 0.98 HIF1A (0.87) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL4002585 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL11911289 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL1692059 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL1639690 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL13839748 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL16393966 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL21051778 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR
Triamcinolone Acetonide SCHEMBL4448 0.94 HIF1A (1.00) HIF1ACYP3A4LMNANR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017003909-A2 CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT CHACHISVILIS MIRIANAS (US) 2017-01-05 — — WO disclosed
CN-102124332-A Separation and manipulation of chiral objects DYNAMIC CONNECTIONS LLC 2011-07-13 — — CN disclosed
EP-2304425-A1 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT Dynamic Connections, Llc (US) 2011-04-06 — — EP disclosed
WO-2009155406-A1 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT DYNAMIC CONNECTIONS, LLC (US) 2009-12-23 — — WO disclosed
EP-2134697-A2 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT Dynamic Connections, Llc (US) 2009-12-23 — — EP disclosed
WO-2008130980-A2 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT DYNAMIC CONNECTIONS, LLC (US) 2008-10-30 — — WO disclosed
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