Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CDC25C | P30307 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780928 | 0.97 | KCNH2 (0.60) | KCNH2CA1CA2MEN1KMT2A | |
| Bromide SCHEMBL10353478 | 0.95 | KCNH2 (0.59) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL8780821 | 0.87 | CHRM2 (0.57) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL9628053 | 0.86 | KCNH2 (0.73) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL11243777 | 0.85 | CHRM2 (0.59) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL7939602 | 0.85 | KCNH2 (0.63) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL991622 | 0.82 | TSHR (0.58) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL8780888 | 0.82 | KCNH2 (0.60) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL24002152 | 0.81 | CHRM2 (0.68) | KCNH2CA1CA2MEN1KMT2A | |
| SCHEMBL16681892 | 0.81 | CA1 (0.77) | KCNH2CA1CA2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |