Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.34 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780988 | 0.94 | KCNH2 (0.41) | ADORA1TAAR1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8780903 | 0.94 | KCNH2 (0.38) | ADORA1SIGMAR1TAAR1KCNH2SLC6A4 | |
| SCHEMBL8780869 | 0.90 | KCNH2 (0.42) | ADORA1TAAR1KCNH2SLC6A4SLC6A3 | |
| SCHEMBL8780752 | 0.85 | MAPT (0.45) | SIGMAR1KCNH2CYP3A4SLC6A4SLC6A3 | |
| SCHEMBL8780889 | 0.85 | SLC22A2 (0.40) | SIGMAR1KCNH2CYP3A4SLC6A4SLC22A2 | |
| SCHEMBL8780940 | 0.85 | ADORA2A (0.43) | ADORA1SIGMAR1KCNH2PKMKMT2A | |
| SCHEMBL8780762 | 0.83 | KCNH2 (0.57) | SIGMAR1KCNH2CYP3A4PKMSLC6A4 | |
| SCHEMBL8780787 | 0.82 | SLC22A2 (0.39) | SIGMAR1TAAR1KCNH2CYP3A4SLC6A4 | |
| SCHEMBL8780859 | 0.81 | SLC22A2 (0.42) | TAAR1KCNH2SLC6A4SLC22A2ADRB1 | |
| SCHEMBL8781003 | 0.81 | KCNH2 (0.50) | SIGMAR1KCNH2SLC6A4SLC6A3RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |