Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.40 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780859 | 0.96 | SLC22A2 (0.42) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780752 | 0.95 | MAPT (0.45) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780903 | 0.92 | KCNH2 (0.38) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780787 | 0.90 | SLC22A2 (0.39) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780869 | 0.88 | KCNH2 (0.42) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780879 | 0.88 | KCNH2 (0.38) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780974 | 0.88 | DRD2 (0.42) | DRD2DRD3CYP3A4CYP2D6TSHR | |
| SCHEMBL8780988 | 0.87 | KCNH2 (0.41) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780967 | 0.85 | ADORA1 (0.39) | SLC22A2ADRB1SLC6A4KCNH2SLC47A2 | |
| SCHEMBL8780776 | 0.85 | MAOA (0.37) | KCNH2MAPTDRD3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697407-B1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS (JP) | 1997-06-25 | — | — | EP | disclosed |
| EP-0697407-A1 | Pyrimidinedione derivatives and antiarrhythmic compositions containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-02-21 | — | — | EP | disclosed |