Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783307 | 0.86 | DRD2 (0.58) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8783610 | 0.85 | DRD2 (0.44) | DRD2DRD3HTR1AHTR7DRD4 | |
| Bromide SCHEMBL9449301 | 0.85 | DRD2 (0.56) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8783021 | 0.76 | DRD2 (0.61) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL30667124 | 0.72 | HTR2A (0.38) | TSHRLMNAGLA | |
| SCHEMBL8788400 | 0.72 | DRD3 (0.47) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8783256 | 0.71 | DRD2 (0.59) | DRD2DRD3HTR1AHTR7DRD4 | |
| Hydrochloric Acid SCHEMBL9449385 | 0.70 | DRD2 (0.58) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8783112 | 0.68 | DRD2 (0.63) | DRD2DRD3HTR1ADRD4HTR1D | |
| SCHEMBL9449401 | 0.68 | DRD2 (0.40) | DRD2DRD3HTR1AHTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| EP-0395244-A1 | Pyridine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |