Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.47 |
| ▸ | DRD2 | P14416 | 11/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784186 | 0.85 | DRD3 (0.48) | DRD3DRD2DRD4HTR1BHTR1D | |
| SCHEMBL8782859 | 0.84 | GRIN2B (0.37) | DRD3DRD2DRD4HTR2AADRA1A | |
| SCHEMBL8783295 | 0.75 | GRIN1 (0.54) | DRD3DRD2DRD4HTR1BHTR1D | |
| SCHEMBL8783307 | 0.74 | DRD2 (0.58) | DRD3DRD2DRD4HTR1DADRB2 | |
| SCHEMBL30667124 | 0.73 | HTR2A (0.38) | HTR2AHTR2B | |
| Bromide SCHEMBL9449301 | 0.73 | DRD2 (0.56) | DRD3DRD2DRD4HTR1DADRB2 | |
| SCHEMBL8314550 | 0.72 | DRD2 (0.60) | DRD3DRD2DRD4HTR1BHTR1D | |
| SCHEMBL9862396 | 0.72 | DRD2 (0.63) | DRD3DRD2DRD4HTR1BHTR1D | |
| SCHEMBL8782868 | 0.72 | DRD2 (0.43) | DRD3DRD2DRD4HTR1DADRB2 | |
| Hydrochloric Acid SCHEMBL9424993 | 0.71 | DRD2 (0.62) | DRD3DRD2DRD4HTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395244-B1 | Pyridine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1997-02-19 | — | — | EP | disclosed |
| US-5194439-A | 5-HT Agonists or Antagonists, Nervous System Disorders, Hypotensive Agents | JOHN WYETH & BROTHER LIMITED (GB) | 1993-03-16 | — | — | US | disclosed |
| US-5075303-A | Central nervous system disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1991-12-24 | — | — | US | disclosed |