Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314202 | 0.90 | DRD2 (0.55) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8314205 | 0.90 | DRD2 (0.55) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8317632 | 0.89 | S1PR5 (0.51) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8317646 | 0.89 | S1PR5 (0.51) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8318715 | 0.88 | RORC (0.51) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8318711 | 0.88 | RORC (0.51) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8782084 | 0.87 | MEN1 (0.54) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8782076 | 0.87 | MEN1 (0.54) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8314188 | 0.87 | MEN1 (0.54) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 | |
| SCHEMBL8314184 | 0.87 | MEN1 (0.54) | S1PR1S1PR5ALDH1A1SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556119-B1 | Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them | ADIR (FR) | 1997-05-14 | — | — | EP | disclosed |
| US-5407946-A | Pyrrolidine compounds which are useful as thromboxane AZ-inhibitors | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| US-5387591-A | Possesses antithromboxane A2 properties; useful in treatment and prevention of thrombotic diseases | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0556119-A1 | Novel pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them | ADIR ET COMPAGNIE (FR) | 1993-08-18 | — | — | EP | disclosed |