Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 | P28472 | 17/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.37 |
| ▸ | GABRP | O00591 | 6/20 | 0.33 |
| ▸ | GABRD | O14764 | 6/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.33 |
| ▸ | GABRE | P78334 | 6/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 2/20 | 0.32 |
| ▸ | BAD | Q92934 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8783141 | 0.91 | CCNE2 (0.35) | BCL2BAD | |
| SCHEMBL7604179 | 0.90 | GABRB3 (0.36) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8783693 | 0.90 | GABRB3 (0.34) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL7604165 | 0.90 | GABRB3 (0.36) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL9394294 | 0.89 | GABRP (0.42) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8329393 | 0.89 | GABRB3 (0.43) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8784237 | 0.81 | MEN1 (0.36) | BCL2BAD | |
| SCHEMBL8783619 | 0.81 | CCNE2 (0.32) | BCL2 | |
| SCHEMBL8326640 | 0.80 | GABRB3 (0.38) | GABRB3GABRA2GABRB2GABRPGABRD | |
| SCHEMBL8506845 | 0.80 | GABRP (0.44) | GABRB3GABRA2GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674625-B1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5668145-A | Amino-substituted pyrazoles having CRF antagonistic activity | PFIZER INC. (US) | 1997-09-16 | — | — | US | disclosed |