Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27388946 | 0.86 | ABL1 (0.49) | ABL1POLBMCOLN3GRIK1NR4A2 | |
| SCHEMBL8784262 | 0.86 | ABL1 (0.50) | ABL1POLBMCOLN3NR4A2MEN1 | |
| SCHEMBL8783964 | 0.83 | POLB (0.45) | ABL1POLBMCOLN3NR4A2MEN1 | |
| SCHEMBL29110277 | 0.80 | CYP11B2 (0.43) | ABL1POLBMCOLN3GRIK1NR4A2 | |
| SCHEMBL8784727 | 0.79 | POLB (0.40) | ABL1POLBMCOLN3MAPTALDH1A1 | |
| SCHEMBL8784194 | 0.78 | CYP4F2 (0.40) | ABL1POLBMCOLN3NR4A2MAPT | |
| SCHEMBL29110340 | 0.78 | POLB (0.48) | ABL1POLBMCOLN3NR4A2MEN1 | |
| SCHEMBL27388939 | 0.73 | ABL1 (0.51) | ABL1POLBMCOLN3GRIK1NR4A2 | |
| SCHEMBL8784285 | 0.73 | POLB (0.42) | ABL1POLBMCOLN3MEN1KMT2A | |
| SCHEMBL6649136 | 0.72 | ABL1 (0.60) | ABL1POLBMCOLN3NR4A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481676-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5559125-A | NMDA AND AMPA RECEPTOR ANTAGONISTS, SCHIZOPHRENIA | MERCK, SHARP & DOHME LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5348962-A | Nervous system disorders; schizophrenia | MERCK SHARPE & DOHME LTD. | 1994-09-20 | — | — | US | disclosed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | disclosed |