Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951178 | 0.97 | P2RY1 (0.64) | P2RY1MEN1POLBMAPTKMT2A | |
| SCHEMBL7857278 | 0.88 | TP53 (0.72) | P2RY1MEN1POLBMAPTKMT2A | |
| SCHEMBL6771045 | 0.81 | EDNRA (0.67) | P2RY1MEN1POLBMAPTKMT2A | |
| SCHEMBL8784088 | 0.81 | EDNRA (0.74) | MEN1KMT2A | |
| SCHEMBL7939780 | 0.81 | EDNRA (0.67) | RAB9A | |
| SCHEMBL8784628 | 0.81 | EDNRA (0.67) | RAB9A | |
| SCHEMBL8785066 | 0.81 | EDNRA (0.67) | — | |
| SCHEMBL7939644 | 0.81 | EDNRA (0.67) | — | |
| SCHEMBL6771238 | 0.80 | EDNRA (0.61) | P2RY1MEN1POLBMAPTKMT2A | |
| SCHEMBL7949150 | 0.79 | EDNRA (0.75) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |