Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.67 |
| ▸ | EDNRB | P24530 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771238 | 0.86 | EDNRA (0.61) | EDNRAEDNRBP2RY1MEN1POLB | |
| SCHEMBL7857278 | 0.83 | TP53 (0.72) | EDNRAEDNRBP2RY1MEN1POLB | |
| SCHEMBL7939644 | 0.82 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL8785066 | 0.82 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL7951178 | 0.82 | P2RY1 (0.64) | ALDH1A1P2RY1MEN1POLBMAPT | |
| SCHEMBL8784309 | 0.81 | P2RY1 (0.63) | P2RY1MEN1POLBMAPTKMT2A | |
| SCHEMBL7850030 | 0.81 | EDNRA (1.00) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL6770134 | 0.79 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL6777190 | 0.79 | EDNRA (0.76) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL9088061 | 0.79 | EDNRA (0.67) | EDNRAEDNRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | claimed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | claimed |
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | disclosed |