Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.53 |
| ▸ | CA2 | P00918 | 9/20 | 0.53 |
| ▸ | CA9 | Q16790 | 9/20 | 0.53 |
| ▸ | CA12 | O43570 | 6/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.46 |
| ▸ | ELF3 | P78545 | 4/20 | 0.46 |
| ▸ | MED23 | Q9ULK4 | 4/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10147612 | 0.98 | CA1 (0.55) | CA1CA2CA9CA12CA14 | |
| SCHEMBL878550 | 0.90 | CA12 (0.45) | CA1CA2CA9CA12CA14 | |
| SCHEMBL878698 | 0.86 | ALB (0.47) | CA1CA2CA9CA12 | |
| SCHEMBL10148185 | 0.79 | HTRA2 (0.35) | — | |
| SCHEMBL861702 | 0.78 | CA12 (0.53) | CA1CA2CA9CA12CA14 | |
| SCHEMBL14032781 | 0.77 | CA9 (0.70) | CA1CA2CA9CA12CA14 | |
| SCHEMBL861474 | 0.76 | CA12 (0.56) | CA1CA2CA9CA12FKBP1A | |
| SCHEMBL860830 | 0.76 | CA12 (0.55) | CA1CA2CA9CA12CA14 | |
| SCHEMBL878334 | 0.75 | ESR1 (0.34) | — | |
| SCHEMBL14032186 | 0.75 | CA9 (0.67) | CA1CA2CA9CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143302-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100254910-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100254910-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | PTGS2, PTGES2, PTGER2 | CA1 305/4885CA2 289/4885CA9 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.