SCHEMBL87863

SCHEMBL87863

NC(=O)CC1c2ccccc2-c2ccccc21

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.59
HTR2A P28223 1/20 0.54
TSHR P16473 2/20 0.49
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
KMT2A Q03164 1/20 0.44
MAPT P10636 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
POLB P06746 1/20 0.41
CYP1A2 P05177 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL42370 0.81 EGFR (0.51) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL1568272 0.81 TSHR (0.50) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL23548026 0.80 EGFR (0.55) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL8254197 0.80 HTR2A (0.57) HSD17B10HTR2ATSHRKMT2A
SCHEMBL7330971 0.80 HSD17B10 (0.42) HSD17B10HTR2ATSHRKMT2AMAPT
SCHEMBL4563067 0.79 HSD17B10 (0.54) HSD17B10KMT2AMAPTPOLBCYP1A2
SCHEMBL8279094 0.79 POLB (0.50) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL87862 0.79 TSHR (0.49) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL2108892 0.79 TSHR (0.49) HSD17B10HTR2ATSHRCA1CA2
SCHEMBL3941411 0.79 ATM (0.59) HSD17B10KMT2AHDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4153561-A2 9H-FLUOREN DERIVATES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS UNIWERSYTET JAGIELLONSKI (PL) 2023-03-29 EP disclosed
US-20220073446-A1 Antigen Delivery Vectors and Constructs ALTIMMUNE UK LIMITED (GB) 2022-03-10 US disclosed
US-11066353-B2 Antigen delivery vectors and constructs ALTIMMUNE UK LTD (GB) 2021-07-20 US disclosed
WO-2021004391-A1 C-MYC PROTEIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 苏州开拓药业股份有限公司 2021-01-14 WO disclosed
EP-3680233-A1 NOVEL AMIDE COMPOUND, AND Pin1 INHIBITOR, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES AND THERAPEUTIC AGENT FOR CANCER THAT USE THE SAME Hiroshima University (JP) 2020-07-15 EP disclosed
CN-108697714-A Novel fused pyrimidine compound or its salt 大鹏药品工业株式会社 2018-10-23 CN disclosed
EP-2374477-B1 Antigen delivery vectors and constructs ALTIMMUNE UK LTD (GB) 2016-09-07 EP disclosed
US-20150112042-A1 Antigen Delivery Vectors and Constructs ALTIMMUNE UK LIMITED (GB) 2015-04-23 US disclosed
US-8759281-B2 Antigen delivery vectors and constructs IMMUNE TARGETING SYSTEMS LTD. (GB) 2014-06-24 US disclosed
CN-102329360-B Dammar-20S, 25R-epoxy-3beta, 12beta, 26-triol and extraction method and drug use thereof UNIV JILIN 2013-01-02 CN disclosed
US-8110540-B2 Antigen delivery vectors and constructs IMMUNE TARGETING SYSTEMS LTD. (GB) 2012-02-07 US disclosed
CN-102329360-A Dammar-20S, 25R-epoxy-3beta, 12beta, 26-triol and extraction method and drug use thereof UNIV JILIN 2012-01-25 CN disclosed
EP-2374477-A1 Antigen delivery vectors and constructs Immune Targeting Systems (GB) 2011-10-12 EP disclosed
US-20100183708-A1 Antigen Delivery Vectors and Constructs IMMUNE TARGETING SYSTEMS LTD. 2010-07-22 US disclosed
US-20100183650-A1 Antigen Delivery Vectors and Constructs IMMUNE TARGETING SYSTEMS LTD. 2010-07-22 US disclosed
US-7687455-B2 comprising fluorocarbon vector-antigen, immunogens; vaccines, immunotherapy IMMUNE TARGETING SYSTEMS LTD. (GB) 2010-03-30 US disclosed
EP-1740207-A2 ANTIGEN DELIVERY VECTORS AND CONSTRUCTS Immune Targeting Systems (GB) 2007-01-10 EP disclosed
US-20060013820-A1 comprising fluorocarbon vector-antigen, immunogens; vaccines, immunotherapy ALTIMMUNE UK LIMITED (GB) 2006-01-19 US disclosed
WO-2005099752-A9 ANTIGEN DELIVERY VECTORS AND CONSTRUCTS IMMUNE TARGETING SYSTEMS (GB) 2005-12-15 WO disclosed
WO-2005099752-A2 ANTIGEN DELIVERY VECTORS AND CONSTRUCTS IMMUNE TARGETING SYSTEMS (GB) 2005-10-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100183650-A1 Antigen Delivery Vectors and Constructs LY96, CD74, CD69 HSD17B10 2989/4885HTR2A 4872/4885TSHR 3438/4885
US-20150112042-A1 Antigen Delivery Vectors and Constructs LY96, CD74, CD69 HSD17B10 2989/4885HTR2A 4872/4885TSHR 3438/4885
US-20100183708-A1 Antigen Delivery Vectors and Constructs LY96, CD74, CD69 HSD17B10 2989/4885HTR2A 4872/4885TSHR 3438/4885
US-20220073446-A1 Antigen Delivery Vectors and Constructs LY96, CD74, CD69 HSD17B10 2989/4885HTR2A 4872/4885TSHR 3438/4885
US-20060013820-A1 comprising fluorocarbon vector-antigen, immunogens; vaccines, immunotherapy LY96, CD74, HAVCR2 HSD17B10 2677/4885HTR2A 4877/4885TSHR 3789/4885
US-11066353-B2 Antigen delivery vectors and constructs LY96, CD74, CD69 HSD17B10 2989/4885HTR2A 4872/4885TSHR 3438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.