Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787481 | 0.85 | CYP3A4 (0.50) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL148384 | 0.84 | MAPT (0.56) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL8759316 | 0.84 | CYP3A4 (0.49) | ALDH1A1MAPTCYP3A4KMT2ATSHR | |
| SCHEMBL8787936 | 0.84 | MAPT (0.55) | ALDH1A1MAPTCYP3A4KMT2ATSHR | |
| SCHEMBL8787638 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL8787027 | 0.83 | CYP3A4 (0.48) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL17368427 | 0.82 | CYP3A4 (0.50) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL8786775 | 0.81 | HTT (0.48) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL11061923 | 0.81 | CYP3A4 (0.64) | ALDH1A1MAPTCYP3A4KDM4EKMT2A | |
| SCHEMBL4288671 | 0.80 | CYP3A4 (0.68) | ALDH1A1MAPTCYP3A4KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508682-B1 | Antibiotic carbapenem derivatives | ZENECA LTD (GB) | 1997-07-23 | — | — | EP | disclosed |
| US-5541178-A | THIENAMYCINS | ZENECA LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| CN-1066657-A | Antimicrobial compounds | ICI PLC (GB) | 1992-12-02 | — | — | CN | disclosed |
| WO-1992017481-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |
| EP-0508682-A1 | Antibiotic carbapenem derivatives | ZENECA LIMITED (GB) | 1992-10-14 | — | — | EP | disclosed |