Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788038 | 1.00 | KMT2A (0.34) | KMT2AALDH1A1MEN1MAPTPOLB | |
| SCHEMBL8787717 | 0.91 | KMT2A (0.36) | KMT2AALDH1A1MEN1MAPTPOLB | |
| SCHEMBL8787737 | 0.88 | KMT2A (0.34) | KMT2AALDH1A1MEN1MAPTPOLB | |
| SCHEMBL8787746 | 0.88 | KMT2A (0.36) | KMT2AALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8787742 | 0.88 | KMT2A (0.34) | KMT2AALDH1A1MEN1MAPTPOLB | |
| Ilonidap SCHEMBL8587849 | 0.86 | ALDH1A1 (0.35) | KMT2AALDH1A1MEN1MAPTPOLB | |
| Ilonidap SCHEMBL8587853 | 0.86 | ALDH1A1 (0.35) | KMT2AALDH1A1MEN1MAPTPOLB | |
| Ilonidap SCHEMBL42518 | 0.86 | ALDH1A1 (0.35) | KMT2AALDH1A1MEN1MAPTPOLB | |
| Ilonidap SCHEMBL9284472 | 0.85 | ALDH1A1 (0.34) | KMT2AALDH1A1MEN1MAPTPOLB | |
| Ilonidap SCHEMBL8788134 | 0.85 | ALDH1A1 (0.34) | KMT2AALDH1A1MEN1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |