Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ilonidap SCHEMBL8587853 | 0.99 | ALDH1A1 (0.35) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| Ilonidap SCHEMBL42518 | 0.99 | ALDH1A1 (0.35) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| Ilonidap SCHEMBL8587849 | 0.99 | ALDH1A1 (0.35) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| Ilonidap SCHEMBL8788348 | 0.98 | ALDH1A1 (0.34) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| Ilonidap SCHEMBL9284472 | 0.98 | ALDH1A1 (0.34) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| Ilonidap SCHEMBL8788132 | 0.98 | ALDH1A1 (0.34) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| SCHEMBL8788043 | 0.85 | KMT2A (0.34) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| SCHEMBL8788038 | 0.85 | KMT2A (0.34) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| SCHEMBL8787717 | 0.84 | KMT2A (0.36) | ALDH1A1KMT2ARXFP1KDM4EPOLB | |
| SCHEMBL9449352 | 0.83 | KDR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681580-B1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER (US) | 1997-07-09 | — | — | EP | disclosed |
| EP-0681580-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES. | PFIZER HOSPITAL PROD (US) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017061-A1 | PRODRUGS OF ANTIINFLAMMATORY 3-ACYL-2-OXINDOLE-1-CARBOXAMIDES | PFIZER INC. (US) | 1994-08-04 | — | — | WO | disclosed |
| US-5270331-A | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides | PFIZER, INC. (US) | 1993-12-14 | — | — | US | disclosed |