Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12487310 | 0.76 | SMN1; SMN2 (0.71) | CYP1A2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL8805502 | 0.72 | MAPK1 (0.44) | CYP1A2CYP3A4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8805183 | 0.70 | CYP3A4 (0.49) | CYP1A2CYP3A4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8662613 | 0.70 | POLB (0.72) | SMN1; SMN2LMNAALDH1A1MAPK1KDM4E | |
| SCHEMBL5763556 | 0.69 | MCL1 (0.49) | CYP1A2SMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL8805181 | 0.68 | ALDH1A1 (0.51) | SMN1; SMN2LMNAALDH1A1MAPK1GAA | |
| SCHEMBL8805496 | 0.68 | ALDH1A1 (0.46) | CYP1A2CYP3A4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9665242 | 0.68 | MAPK1 (0.70) | CYP1A2CYP3A4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4710194 | 0.68 | SMN1; SMN2 (0.58) | CYP1A2CYP3A4SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8663192 | 0.68 | NPC1 (0.53) | CYP1A2CYP3A4SMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684241-B1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-08-27 | — | — | EP | disclosed |
| EP-0684241-A1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-11-29 | — | — | EP | disclosed |