Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24923284 | 0.81 | EPHX1 (0.36) | PDE4BEPHX1GAATP53CYP3A4 | |
| SCHEMBL1296115 | 0.78 | EPHX1 (0.41) | PDE4BEPHX1GAATP53CYP3A4 | |
| SCHEMBL12892156 | 0.78 | GABRR1 (0.34) | EPHX1GAAHRH3 | |
| SCHEMBL12877873 | 0.78 | GABRR1 (0.34) | EPHX1GAAHRH3 | |
| SCHEMBL8905563 | 0.77 | EPHX1 (0.33) | EPHX1GAATP53CYP3A4HRH3 | |
| SCHEMBL26460992 | 0.73 | EPHX1 (0.52) | PDE4BEPHX1GAACTSKTP53 | |
| SCHEMBL8789060 | 0.73 | PEPD (0.38) | MEN1ALDH1A1KMT2A | |
| SCHEMBL1296980 | 0.72 | BTK (0.44) | EPHX1GAAALDH1A1 | |
| SCHEMBL7684286 | 0.72 | CA1 (0.38) | PDE4BEPHX1GAATP53CYP3A4 | |
| SCHEMBL1296390 | 0.72 | SLC6A2 (0.46) | PDE4BEPHX1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | claimed |
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |