Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24923284 | 0.81 | EPHX1 (0.36) | EPHX1GAATP53CYP3A4HRH3 | |
| SCHEMBL1296115 | 0.78 | EPHX1 (0.41) | EPHX1GAATP53CYP3A4HRH3 | |
| SCHEMBL12877873 | 0.78 | GABRR1 (0.34) | EPHX1GAAHRH3 | |
| SCHEMBL12892156 | 0.78 | GABRR1 (0.34) | EPHX1GAAHRH3 | |
| SCHEMBL8788545 | 0.77 | PDE4B (0.34) | EPHX1GAATP53CYP3A4HRH3 | |
| SCHEMBL8788736 | 0.73 | PEPD (0.38) | — | |
| SCHEMBL26460992 | 0.73 | EPHX1 (0.52) | EPHX1GAATP53CYP3A4HRH3 | |
| SCHEMBL1296382 | 0.72 | TP53 (0.41) | EPHX1TP53CYP3A4 | |
| SCHEMBL1296980 | 0.72 | BTK (0.44) | EPHX1GAA | |
| SCHEMBL7684286 | 0.72 | CA1 (0.38) | EPHX1GAATP53CYP3A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |