Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | MAX | P61244 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788464 | 0.90 | PRSS1 (0.47) | KMT2AKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL15956338 | 0.88 | ALDH1A1 (0.47) | ARPELP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30669433 | 0.88 | AR (0.56) | ARPELP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4983306 | 0.88 | AR (0.56) | ARPELP1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10319262 | 0.87 | MAPT (0.47) | KMT2AKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL8787481 | 0.84 | CYP3A4 (0.50) | KMT2AKDM4EALDH1A1SNCACYP3A4 | |
| SCHEMBL1459781 | 0.83 | TSHR (0.56) | KMT2AKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL13690626 | 0.82 | KDM4E (0.57) | KMT2AKDM4EALDH1A1SNCACYP3A4 | |
| SCHEMBL2705489 | 0.81 | CYP3A4 (0.50) | KMT2AKDM4EALDH1A1SNCACYP3A4 | |
| SCHEMBL753770 | 0.81 | KMT2A (0.45) | KMT2AKDM4EALDH1A1SNCACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508682-B1 | Antibiotic carbapenem derivatives | ZENECA LTD (GB) | 1997-07-23 | — | — | EP | disclosed |
| US-5541178-A | THIENAMYCINS | ZENECA LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| CN-1066657-A | Antimicrobial compounds | ICI PLC (GB) | 1992-12-02 | — | — | CN | disclosed |
| WO-1992017481-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |
| EP-0508682-A1 | Antibiotic carbapenem derivatives | ZENECA LIMITED (GB) | 1992-10-14 | — | — | EP | disclosed |