Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.66 |
| ▸ | MYC | P01106 | 6/20 | 0.66 |
| ▸ | IDO1 | P14902 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAX | P61244 | 2/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | MIF | P14174 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052057 | 0.85 | GSTM2 (0.66) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL612306 | 0.85 | IDO1 (0.65) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL27934659 | 0.85 | MEN1 (0.64) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL593192 | 0.85 | MEN1 (0.64) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL7904806 | 0.85 | MEN1 (0.64) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL9099360 | 0.85 | MEN1 (0.64) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL8788860 | 0.84 | MEN1 (0.67) | MEN1KMT2AMYCIDO1POLB | |
| Hydrazine SCHEMBL28939827 | 0.83 | MEN1 (0.62) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL14266890 | 0.82 | MEN1 (0.61) | MEN1KMT2AMYCIDO1POLB | |
| SCHEMBL12337785 | 0.81 | IDO1 (0.60) | MEN1KMT2AMYCIDO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | claimed |
| EP-0468470-A1 | Benzimidazoles, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-01-29 | — | — | EP | claimed |
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| EP-0468470-B1 | Benzimidazoles, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | EP | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |
| EP-0468470-A1 | Benzimidazoles, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-01-29 | — | — | EP | disclosed |