Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | BUB1 | O43683 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788576 | 0.86 | KMT2A (0.53) | KMT2AKDM4EMEN1BUB1RAD52 | |
| SCHEMBL19660760 | 0.82 | ALDH1A1 (0.55) | KMT2AKDM4EMEN1MAPTL3MBTL1 | |
| SCHEMBL29433439 | 0.72 | CYP2A6 (0.37) | KMT2AKDM4EMEN1BUB1NPC1 | |
| SCHEMBL4187399 | 0.72 | APP (0.38) | KMT2AKDM4EMEN1BUB1NPC1 | |
| SCHEMBL28702492 | 0.72 | CYP2A6 (0.37) | KMT2AKDM4EMEN1BUB1NPC1 | |
| SCHEMBL28365072 | 0.71 | ALDH1A1 (0.70) | KMT2AKDM4EMEN1RAD52NPC1 | |
| SCHEMBL20712207 | 0.70 | KMT2A (0.50) | KMT2AKDM4EMEN1RAD52NPC1 | |
| SCHEMBL725063 | 0.69 | RAD52 (0.70) | KMT2AKDM4EMEN1RAD52MAPT | |
| SCHEMBL25262011 | 0.69 | KMT2A (0.68) | KMT2AKDM4EMEN1RAD52NPC1 | |
| SCHEMBL31114573 | 0.69 | KMT2A (0.68) | KMT2AKDM4EMEN1RAD52NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534343-B1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1997-11-19 | — | — | EP | disclosed |
| US-5631270-A | COGNITION ACTIVATORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5424322-A | Substituted pyridinylamino-1h-indole derivatives | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-13 | — | — | US | disclosed |
| US-5328918-A | Psychological disorders, antiinflammatory agent | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5246947-A | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-09-21 | — | — | US | disclosed |
| US-5229401-A | Cognition activators; Alzheimer's disease; psychological disorders,e.g obsessive-compulsive; antidepressants; topical antinflammatory agent; skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0534343-A1 | Substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo(b) thiophenes and 1,2-benzisothiazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5185350-A | For Alzheimer*s, memory dysfunctions, antidepressants, antiinflammatory agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-02-09 | — | — | US | disclosed |