Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.54 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790478 | 0.93 | KCNH2 (0.76) | KCNH2HRH3AOC3SMPD1SIGMAR1 | |
| SCHEMBL8789557 | 0.89 | AOC3 (0.66) | KCNH2AOC3SMPD1SIGMAR1SLC6A2 | |
| SCHEMBL8790115 | 0.88 | AOC3 (0.57) | KCNH2AOC3SMPD1SIGMAR1SLC6A2 | |
| SCHEMBL7024969 | 0.86 | KCNH2 (0.73) | KCNH2HRH3AOC3SIGMAR1CACNA1F | |
| SCHEMBL8789951 | 0.85 | CYP3A4 (0.65) | KCNH2AOC3SMPD1SLC6A4CACNA1F | |
| SCHEMBL30354887 | 0.81 | NPC1 (0.68) | KCNH2AOC3TAAR1 | |
| SCHEMBL8789805 | 0.80 | KCNH2 (0.83) | KCNH2HRH3SIGMAR1ACHE | |
| SCHEMBL8789857 | 0.79 | TSHR (0.73) | KCNH2HRH3ACHE | |
| SCHEMBL8790447 | 0.79 | AOC3 (0.53) | AOC3SMPD1SIGMAR1TAAR1ACHE | |
| SCHEMBL9160564 | 0.79 | AOC3 (0.60) | KCNH2AOC3SMPD1SIGMAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |