SCHEMBL8790478

SCHEMBL8790478

COc1ccc(CCN(C)CCOc2ccc(N)cc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.76
HRH3 Q9Y5N1 2/20 0.55
AOC3 Q16853 2/20 0.55
TSHR P16473 1/20 0.55
CACNA1F O60840 1/20 0.54
CHRM2 P08172 1/20 0.54
ACHE P22303 1/20 0.54
AGTR1 P30556 1/20 0.54
DRD3 P35462 1/20 0.54
CACNA1D Q01668 1/20 0.54
CACNA1S Q13698 1/20 0.54
CACNA1C Q13936 1/20 0.54
SIGMAR1 Q99720 1/20 0.51
DRD2 P14416 1/20 0.50
SLC6A2 P23975 1/20 0.50
SLC6A4 P31645 1/20 0.50
SLC6A3 Q01959 1/20 0.50
TAAR1 Q96RJ0 1/20 0.49
SMPD1 P17405 1/20 0.48
CYP19A1 P11511 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7024969 0.94 KCNH2 (0.73) KCNH2HRH3AOC3TSHRCACNA1F
SCHEMBL8789232 0.93 KCNH2 (0.66) KCNH2HRH3AOC3CACNA1FCHRM2
SCHEMBL8789557 0.91 AOC3 (0.66) KCNH2AOC3SIGMAR1SLC6A2SLC6A4
SCHEMBL8789857 0.87 TSHR (0.73) KCNH2HRH3TSHRACHEDRD2
SCHEMBL6575217 0.85 CYP1A2 (0.67) KCNH2AOC3SMPD1CYP19A1
Hydrochloric Acid SCHEMBL9054039 0.84 BLM (0.68) KCNH2AOC3SMPD1CYP19A1
SCHEMBL2022333 0.84 KCNH2 (0.56) KCNH2HRH3TSHRCACNA1FCHRM2
SCHEMBL8790115 0.84 AOC3 (0.57) KCNH2AOC3SIGMAR1SLC6A2SLC6A4
SCHEMBL30354887 0.82 NPC1 (0.68) KCNH2AOC3TSHRTAAR1CYP19A1
SCHEMBL9628264 0.82 KCNH2 (0.58) KCNH2HRH3CACNA1FCHRM2ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0569380-B1 ACRIDINE DERIVATIVES GLAXO LAB SA (FR) 1997-05-28 EP disclosed
US-5604237-A IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT LABORATOIRES GLAXO SA (FR) 1997-02-18 US disclosed
EP-0494623-A1 Acridine derivatives LABORATOIRES GLAXO SA (FR) 1992-07-15 EP disclosed