Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791123 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8791432 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8791140 | 0.78 | ALDH1A1 (0.35) | ALDH1A1HPGDKMT2AHSD11B1MAPK8 | |
| SCHEMBL8790955 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8790845 | 0.75 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8947097 | 0.74 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4CMAPTHSD11B1 | |
| SCHEMBL8790797 | 0.73 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8947245 | 0.72 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CMAPTHSD11B1 | |
| SCHEMBL8791721 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CMAPTKMT2A | |
| SCHEMBL8790981 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |