Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791041 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8792333 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8790264 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8791024 | 0.77 | ALDH1A1 (0.33) | ALDH1A1HPGDKMT2AHSD11B1 | |
| SCHEMBL8790795 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8791245 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8790076 | 0.75 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 | |
| SCHEMBL8790035 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDKDM4CKMT2AMAPT | |
| SCHEMBL8792681 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4CKMT2ATSHR | |
| SCHEMBL8790981 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4CKMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |