SCHEMBL8790099

SCHEMBL8790099

CCCCc1nc(Cl)c(COCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccoc2C(=O)O)cc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.61
AGTR2 P50052 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8791754 0.89 AGTR1 (0.77) AGTR1AGTR2
SCHEMBL8792075 0.85 AGTR1 (0.65) AGTR1AGTR2
SCHEMBL9275255 0.85 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL8791528 0.84 AGTR1 (0.71) AGTR1AGTR2
SCHEMBL8791379 0.83 AGTR1 (0.60) AGTR1AGTR2
SCHEMBL8790075 0.81 AGTR2 (0.64) AGTR1AGTR2
SCHEMBL8791032 0.81 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL8791197 0.80 AGTR1 (0.75) AGTR1AGTR2
SCHEMBL9273740 0.80 AGTR1 (0.54) AGTR1AGTR2
SCHEMBL8791749 0.80 AGTR1 (0.59) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0652869-B1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY LUSO FARMACO INST (IT) 1997-03-26 EP claimed
US-5538987-A Imidazole ethers having a II antagonist activity ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1996-07-23 US claimed
EP-0652869-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY. LUSO FARMACO INST (IT) 1995-05-17 EP claimed
WO-1994002467-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1994-02-03 WO claimed
EP-0652869-B1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY LUSO FARMACO INST (IT) 1997-03-26 EP disclosed
US-5538987-A Imidazole ethers having a II antagonist activity ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1996-07-23 US disclosed
EP-0652869-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY. LUSO FARMACO INST (IT) 1995-05-17 EP disclosed
WO-1994002467-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1994-02-03 WO disclosed