Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 15/20 | 0.61 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789667 | 0.93 | ABCB1 (0.67) | ABCB1DHCR7ABCG2 | |
| SCHEMBL8790535 | 0.87 | ABCB1 (0.68) | ABCB1DHCR7ABCG2 | |
| SCHEMBL8790676 | 0.85 | DHCR7 (0.61) | ABCB1DHCR7ABCG2 | |
| SCHEMBL8788946 | 0.83 | ABCB1 (0.67) | ABCB1DHCR7ABCG2 | |
| SCHEMBL4663782 | 0.83 | SIGMAR1 (0.63) | ABCB1 | |
| SCHEMBL8790359 | 0.80 | ABCB1 (0.57) | ABCB1DHCR7ABCG2 | |
| SCHEMBL2771882 | 0.79 | ABCB1 (0.78) | ABCB1DHCR7ABCG2 | |
| SCHEMBL13896162 | 0.79 | ABCB1 (0.73) | ABCB1DHCR7ABCG2 | |
| Hydrochloric Acid SCHEMBL10661663 | 0.78 | ABCB1 (0.76) | ABCB1DHCR7ABCG2 | |
| SCHEMBL4049215 | 0.78 | ABCB1 (0.75) | ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |