Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.68 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8788946 | 0.96 | ABCB1 (0.67) | ABCB1ABCG2DHCR7KMT2A | |
| SCHEMBL2771882 | 0.92 | ABCB1 (0.78) | ABCB1ABCG2DHCR7KMT2A | |
| Hydrochloric Acid SCHEMBL10661663 | 0.91 | ABCB1 (0.76) | ABCB1ABCG2DHCR7KMT2A | |
| SCHEMBL8790676 | 0.88 | DHCR7 (0.61) | ABCB1ABCG2DHCR7KMT2A | |
| SCHEMBL8790248 | 0.87 | ABCB1 (0.61) | ABCB1ABCG2DHCR7 | |
| Verilopam SCHEMBL489188 | 0.85 | ABCB1 (0.68) | ABCB1ABCG2DHCR7KMT2A | |
| SCHEMBL14330769 | 0.84 | DHCR7 (0.79) | ABCB1ABCG2DHCR7 | |
| SCHEMBL17664977 | 0.84 | DHCR7 (0.79) | ABCB1ABCG2DHCR7 | |
| Verilopam SCHEMBL121615 | 0.84 | ABCB1 (0.67) | ABCB1ABCG2DHCR7KMT2A | |
| SCHEMBL3810641 | 0.84 | KMT2A (0.76) | ABCB1ABCG2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0569380-B1 | ACRIDINE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-28 | — | — | EP | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |
| US-5604237-A | IMPROVE OR INCREASE EFFICACY OF ANTITUMOR AGENT, INCREASE OR RESTORE SENSITIVITY OF TUMOR TO ANTITUMOR AGENT, REVERSE OR REDUCE RESISTANCE OF TUMOR TO ANTITUMOR AGENT | LABORATOIRES GLAXO SA (FR) | 1997-02-18 | — | — | US | disclosed |
| EP-0649410-A1 | ANILIDE DERIVATIVES. | GLAXO LAB SA (FR) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001408-A1 | ANILIDE DERIVATIVES | LABORATOIRES GLAXO S.A. (FR) | 1994-01-20 | — | — | WO | disclosed |
| EP-0494623-A1 | Acridine derivatives | LABORATOIRES GLAXO SA (FR) | 1992-07-15 | — | — | EP | disclosed |