Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791140 | 0.85 | ALDH1A1 (0.35) | MAPK8MAPK10TSHRALDH1A1HSD11B1 | |
| SCHEMBL8790825 | 0.84 | PLA2G10 (0.35) | MAPK8MAPK10ALDH1A1HSD11B1 | |
| SCHEMBL8791208 | 0.82 | MAPK8 (0.34) | MAPK8MAPK10ALDH1A1 | |
| SCHEMBL8792325 | 0.80 | MAPK8 (0.33) | MAPK8MAPK10ALDH1A1 | |
| SCHEMBL8791553 | 0.78 | MAPK8 (0.32) | MAPK8MAPK10 | |
| SCHEMBL8791633 | 0.77 | CYP2A6 (0.38) | TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL8790385 | 0.76 | MAPK8 (0.31) | MAPK8MAPK10ALDH1A1 | |
| SCHEMBL8790885 | 0.75 | ALDH1A1 (0.32) | MAPK8MAPK10ALDH1A1 | |
| SCHEMBL8791026 | 0.74 | MAPT (0.30) | MAPT | |
| Hydrochloric Acid SCHEMBL8973456 | 0.74 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-RE35321-E | ANTIDIABETIC AGENT | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| US-5068239-A | Antidiabetic agent | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |