Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8973456 | 0.99 | ALDH1A1 (0.31) | ALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL8791633 | 0.86 | CYP2A6 (0.38) | ALDH1A1 | |
| SCHEMBL8790385 | 0.84 | MAPK8 (0.31) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8791593 | 0.82 | HSD11B1 (0.36) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8790106 | 0.80 | ALDH1A1 (0.36) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8790825 | 0.79 | PLA2G10 (0.35) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8791028 | 0.78 | KMT2A (0.32) | ALDH1A1 | |
| SCHEMBL8791208 | 0.77 | MAPK8 (0.34) | ALDH1A1MAPK8MAPK10 | |
| SCHEMBL8791602 | 0.76 | L3MBTL1 (0.40) | ALDH1A1 | |
| SCHEMBL8790766 | 0.76 | KMT2A (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421365-B1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMA CO LTD (JP) | 1997-03-05 | — | — | EP | disclosed |
| EP-0421365-A2 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1991-04-10 | — | — | EP | disclosed |