Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.93 |
| ▸ | HTR1A | P08908 | 2/20 | 0.93 |
| ▸ | HTR6 | P50406 | 9/20 | 0.76 |
| ▸ | HTR1D | P28221 | 5/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790496 | 1.00 | HTR1B (0.93) | HTR1BHTR1AHTR6HTR1DHTR2A | |
| SCHEMBL8790464 | 0.96 | HTR1B (1.00) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL5819877 | 0.96 | HTR1B (1.00) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL5819875 | 0.96 | HTR1B (1.00) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8791176 | 0.92 | HTR1B (0.86) | HTR1BHTR1AHTR6HTR1DHTR2A | |
| SCHEMBL8791182 | 0.92 | HTR1B (0.86) | HTR1BHTR1AHTR6HTR1DHTR2A | |
| SCHEMBL8876146 | 0.92 | HTR1B (0.86) | HTR1BHTR1AHTR6HTR1DHTR2A | |
| SCHEMBL30675338 | 0.90 | HTR1B (0.87) | HTR1BHTR1AHTR6HTR1DHTR2A | |
| SCHEMBL8201469 | 0.86 | HTR6 (1.00) | HTR1BHTR1AHTR6HTR1D | |
| SCHEMBL8201472 | 0.86 | HTR6 (1.00) | HTR1BHTR1AHTR6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9003063-A | — | — | None | — | — | JP | disclosed |
| EP-0592438-B1 | INDOLE DERIVATIVES | PFIZER (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5607951-A | SEROTONIN AGONIST FOR NERVOUS SYSTEM DISORDERS, ANALGESICS AND PSYCHOTHERAPEUTICS | PFIZER INC (US) | 1997-03-04 | — | — | US | disclosed |
| JP-H093063-A | PIPERIDINYLMETHYL SUBSTITUTED INDOLE DERIVATIVE | PFIZER INC | 1997-01-07 | — | — | JP | disclosed |
| EP-0747353-A2 | Indole derivatives | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5578612-A | Indole derivatives | PFIZER INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5559246-A | PROCESS OF DEHYDROHALOGENATION FOR CYCLIZATION TO PRODUCE PSYCHOTHERAPEUTIC AGENTS AND ANTISEROTONIN ANTAGONIST | PFIZER INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5559129-A | SEROTONIN (5HT1) ANTAGONIST FOR TREATMENT OF DEPRESSION, ANXIETY, EATING DISORDERS, OBESITY, DRUG ABUSE, HEADACHES, AND PAIN | PFIZER INC (US) | 1996-09-24 | — | — | US | disclosed |
| US-5545644-A | SEROTONIN AGONISTS; HYPOTENSIVE AND ANXIOLYTIC AGENTS; ANALGESICS; ANTIDEPRESSANTS; EATING DISORDERS; DRUG ABUSE; HEADACHES; VASCULAR DISORDERS | PFIZER INC. (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1992006973-A1 | INDOLE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | disclosed |