Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CETP | P11597 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491870 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL5016073 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL12491826 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL12490849 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL12491704 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL7495807 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL12491106 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL16848408 | 1.00 | LMNA (0.54) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL10609224 | 0.98 | LMNA (0.50) | LMNACYP2D6SPHK1GMNNPOLB | |
| SCHEMBL525696 | 0.91 | ALDH1A1 (0.46) | LMNACYP2D6SPHK1GMNNPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0534258-B1 | Chiral oxazolines as dopants for liquid crystals mixtures | HOFFMANN LA ROCHE (CH) | 1997-05-21 | — | — | EP | disclosed |
| US-5518653-A | LIQUID CRYSTAL | HOFFMANN-LA ROCHE INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0457105-B1 | Chiral dioxanes as components of liquid crystal mixtures | HOFFMANN LA ROCHE (CH) | 1995-07-26 | — | — | EP | disclosed |
| US-5360577-A | MIXTURE OF OPTICALLY ACTIVE OXAZOLINE COMPOUND AND A LIQUID CRYSTALLINE CARRIER | HOFFMANN-LA ROCHE INC. (US) | 1994-11-01 | — | — | US | disclosed |
| EP-0534258-A1 | Chiral oxazolines as dopants for liquid crystals mixtures | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-31 | — | — | EP | disclosed |
| EP-0457105-A1 | Chiral dioxanes as components of liquid crystal mixtures | F. HOFFMANN-LA ROCHE AG (CH) | 1991-11-21 | — | — | EP | disclosed |