SCHEMBL8790610

SCHEMBL8790610

CN1C(C)(C)CC(OC(=O)/C=C\C(=O)OC2CC(C)(C)N(C)C(C)(C)C2)CC1(C)C

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.35
KMT2A Q03164 2/20 0.35
HTT P42858 2/20 0.34
GAA P10253 2/20 0.34
ALDH1A1 P00352 1/20 0.33
ESR1 P03372 1/20 0.33
HSD17B10 Q99714 1/20 0.33
NFKB1 P19838 1/20 0.32
CYP2C19 P33261 1/20 0.32
CYP2D6 P10635 1/20 0.31
LMNA P02545 1/20 0.31
MEN1 O00255 1/20 0.30
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30
HCAR2 Q8TDS4 1/20 0.30
HSD11B1 P28845 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10707940 1.00 TSHR (0.35) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL8790619 1.00 TSHR (0.35) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL9718978 0.93 HCAR2 (0.38) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL9718974 0.93 HCAR2 (0.38) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL5422213 0.91 TSHR (0.33) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL5422202 0.91 TSHR (0.33) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL13588319 0.90 GAA (0.43) TSHRKMT2AHTTGAA
SCHEMBL21911139 0.87 TSHR (0.31) TSHRKMT2AHTTGAA
SCHEMBL69507 0.85 TSHR (0.33) TSHRKMT2AHTTGAAALDH1A1
SCHEMBL18534067 0.85 TSHR (0.33) TSHRKMT2AHTTGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634412-B1 Piperidine compounds for use as stabilizers for organic materials CIBA GEIGY (CH) 1997-06-25 EP disclosed
EP-0634412-A1 Piperidine compounds for use as stabilizers for organic materials CIBA-GEIGY AG (CH) 1995-01-18 EP disclosed
US-4499220-A Copolymer light stabilizers having at least one 2,2,6,6-tetraalkyl piperidyl group and synthetic resin compositions containing the same ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1985-02-12 US disclosed
US-4487887-A PHOTOSTABILITY ADEKA ARGUS CHEMICAL CO., LTD. (JP) 1984-12-11 US disclosed