Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 6/20 | 0.41 |
| ▸ | CCND1 | P24385 | 6/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | PRKACG | P22612 | 2/20 | 0.39 |
| ▸ | PRKACB | P22694 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844615 | 0.85 | CDK4 (0.49) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844918 | 0.77 | PIM3 (0.56) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL12234734 | 0.70 | PIM3 (0.62) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL860074 | 0.69 | AHR (0.50) | AHRTNFRIPK1ARCMA1 | |
| SCHEMBL844739 | 0.69 | PIM3 (0.55) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844551 | 0.68 | KIF11 (0.61) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL845017 | 0.68 | PIM3 (0.79) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844646 | 0.67 | PIM3 (1.00) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL31060188 | 0.67 | PIM3 (1.00) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL15826435 | 0.66 | RHEB (0.50) | AHRALDH1A1CMA1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | disclosed |