Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.49 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272806 | 0.93 | AGTR1 (0.45) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL3630129 | 0.90 | AGTR1 (0.53) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL8791077 | 0.89 | AGTR1 (0.52) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL10053021 | 0.87 | AGTR1 (0.55) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL6891884 | 0.86 | AGTR1 (0.56) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL17653793 | 0.86 | AGTR1 (0.54) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL28274270 | 0.85 | AGTR1 (0.66) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| Losartan SCHEMBL21121033 | 0.85 | AGTR1 (0.58) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL13755335 | 0.85 | AGTR1 (0.58) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL10021557 | 0.85 | AGTR1 (0.53) | AGTR1AGTR2ABCC4ABCB11PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538987-A | Imidazole ethers having a II antagonist activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1996-07-23 | — | — | US | claimed |
| EP-0652869-A1 | IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY. | LUSO FARMACO INST (IT) | 1995-05-17 | — | — | EP | claimed |
| WO-1994002467-A1 | IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY | INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-02-03 | — | — | WO | claimed |
| EP-0652869-B1 | IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY | LUSO FARMACO INST (IT) | 1997-03-26 | — | — | EP | disclosed |
| US-5538987-A | Imidazole ethers having a II antagonist activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1996-07-23 | — | — | US | disclosed |
| WO-1994002467-A1 | IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY | INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1994-02-03 | — | — | WO | disclosed |