Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8100697 | 0.99 | HRH3 (0.62) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| Bromide SCHEMBL8110043 | 0.94 | HRH3 (0.63) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL7306800 | 0.91 | HRH3 (0.62) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL3604079 | 0.85 | HRH3 (0.66) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL10196775 | 0.85 | HRH3 (0.66) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL9815940 | 0.84 | MAPT (0.64) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL10963711 | 0.82 | LMNA (0.65) | HRH3LMNAKCNH2CHRM2SLC6A2 | |
| SCHEMBL8114174 | 0.79 | MAPT (0.74) | HRH3LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8794939 | 0.79 | CYP19A1 (0.43) | HRH3CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL10969675 | 0.79 | LMNA (0.69) | HRH3LMNAKCNH2CHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751132-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1997-01-02 | — | — | EP | disclosed |