SCHEMBL8791939

SCHEMBL8791939

CCCCc1nc(Cl)c(COc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2)c(C(=O)O)c1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.66
AGTR2 P50052 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8791634 0.92 AGTR1 (0.78) AGTR1AGTR2
SCHEMBL9082187 0.91 AGTR2 (0.61) AGTR1AGTR2
SCHEMBL10589434 0.88 AGTR1 (0.82) AGTR1AGTR2
SCHEMBL8792075 0.87 AGTR1 (0.65) AGTR1AGTR2
SCHEMBL9273805 0.86 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL8791194 0.85 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL10589740 0.84 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL8794230 0.83 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL8791818 0.83 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL8791749 0.83 AGTR1 (0.59) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0652869-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY. LUSO FARMACO INST (IT) 1995-05-17 EP claimed
EP-0652869-B1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY LUSO FARMACO INST (IT) 1997-03-26 EP disclosed
US-5538987-A Imidazole ethers having a II antagonist activity ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1996-07-23 US disclosed
EP-0652869-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY. LUSO FARMACO INST (IT) 1995-05-17 EP disclosed
WO-1994002467-A1 IMIDAZOLE ETHERS HAVING A II ANTAGONIST ACTIVITY INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1994-02-03 WO disclosed