Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.59 |
| ▸ | HTR1B | P28222 | 9/20 | 0.59 |
| ▸ | HTR2A | P28223 | 9/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935768 | 0.95 | HTR1D (0.65) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8793036 | 0.80 | HTR1D (0.71) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8795470 | 0.78 | HTR1D (0.62) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8795276 | 0.78 | HTR1D (0.44) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL7450572 | 0.77 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8794661 | 0.76 | HTR1D (0.58) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8570942 | 0.75 | HTR1D (0.78) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8569674 | 0.74 | HTR1D (1.00) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8687667 | 0.74 | HTR1D (0.77) | HTR1DHTR1BHTR2AMEN1MAPT | |
| SCHEMBL8564809 | 0.73 | HTR1D (0.75) | HTR1DHTR1BHTR2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763034-A1 | AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995032967-A1 | AMIDE DERIVATIVES HAVING 5HT1D-ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-12-07 | — | — | WO | disclosed |